The model was used to investigate three different transmembrane pressures and three different cross-flow velocities during a back-shock cycle. The net flux was found to increase under all operating conditions when using back-shocking. The greatest increase in normalized net flux was found at the highest cross-flow velocity and the highest transmembrane pressure, and corresponds to an increase of 37% compared to the steady-state flux. The highest cross-flow velocity and the highest transmembrane pressure gave the highest optimal back-shock frequency of 0.21 Hz. The optimal back-shock frequency was found to decrease with increasing pressure and decreasing cross-flow velocity.
The model is easy to use in different applications as it is easy to measure flux during forward filtration without back-shocking. Good agreement was found between the semi-analytical model and a model based on computer fluid dynamics in predicting both the value of the optimal normalized net flux and the optimal back-shock frequency.