- 作者：Hans Strid ; Magnus Simr茅n ; Anders Lasson ; Stefan Isaksson ; Mats Stridsberg ; Lena 脰hman
- 关键词：IBD ; Ulcerative colitis ; Chromogranin ; Secretogranin
- 刊名：Journal of Crohn's and Colitis
- 出版年：15 December, 2013
- 年：2013
- 卷：7
- 期：12
- 页码：e615-e622
- 全文大小：635 K
Background
Little is known of the importance of chromogranins (Cg) and secretogranins (Sg) in ulcerative colitis (UC). We therefore investigated fecal levels of CgA, CgB, SgII and SgIII, and their association with inflammatory activity, disease duration and medical therapy in UC.Methods
Analyses of CgA, CgB, SgII, SgIII and calprotectin in stool samples from 41 UC patients and 29 healthy controls were performed. Two stool samples, during relapse and remission, respectively, were obtained from each UC patient.
Results
The levels of fecal CgA and SgII were higher in UC patients with active disease as compared to healthy controls. CgB and SgII were positively correlated with disease duration, but none of the granins were positively correlated with calprotectin, Mayo score, CRP or serum concentrations of TNF in UC patients with active disease. Also UC patients in remission had higher levels of CgA, CgB, SgII, and SgIII as compared to healthy controls. However, levels of fecal CgA, CgB, SgII and SgIII were lower during active disease relative to remission. Moreover, fecal levels of CgA and SgII were higher in UC patients in remission treated with thiopurines than in thiopurine-na茂ve patients in remission.
Conclusion
Fecal chromogranins and secretogranins are increased in UC but are not associated with disease activity, but seem to increase with duration of the disease. Thus, fecal granins might reflect structural changes associated with chronicity of disease, or medical therapy.