A ten fold reduction of nicotine yield in tobacco smoke does not spare the central cholinergic system in adolescent mice
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- 作者：Yael Abreu-Villaç ; aa ; yael_a_v@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author ; Monique Correa-Santosa ; Ana C. Dutra-Tavaresa ; Danielle Paes-Brancoa ; Andre Nunes-Freitasa ; Alex C. Manhã ; esa ; Clá ; udio C. Filgueirasa ; Anderson Ribeiro-Carvalhob
- 关键词：AChE ; acetylcholinesterase ; ChAT ; choline acetyltransferase ; CHT ; high-affinity presynaptic choline transporter and activities ; CT ; control ; HighNic ; tobacco smoke with high nicotine levels ; LowNic ; tobacco smoke with very low nicotine levels ; nAChRs ; nicotinic acetylcholine receptors ; PN ; postnatal day
- 刊名：International Journal of Developmental Neuroscience
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：52
- 期：Complete
- 页码：93-103
- 全文大小：684 K
文摘
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Adolescent mice were exposed very low or high nicotine levels in tobacco smoke.
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The pattern of cholinergic effects is distinct in HighNic vs. LowNic mice.
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The cholinergic effects differ during, shortly or long after exposure.
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Reduction of nicotine yield in tobacco does not spare the central cholinergic system.