The interphase mammalian chromosome as a structural system based on tensegrity
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- 作者：Armando Aranda-Anzaldo ; aaa@uaemex.mx" class="auth_mail" title="E-mail the corresponding author ; armandoa10@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：DNA loops ; DNA topology ; Entropy ; Nuclear matrix ; Nuclear higher-order structure
- 刊名：Journal of Theoretical Biology
- 出版年：2016
- 出版时间：21 March 2016
- 年：2016
- 卷：393
- 期：Complete
- 页码：51-59
- 全文大小：810 K
文摘
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Entropy promotes primary condensation of DNA in the interphase nucleus.
Dissipation of torsional stress determines the organization of chromosomal DNA.
Each chromosome is organized in supercoiled loops anchored to the nuclear matrix (NM).
The interactions DNA–NM preserve the molecular integrity of chromosomal DNA.
The interphase organization of chromosomal DNA is based on structural tensegrity.