Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis

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• 作者：Elie El Agha¹ ; Alena Moiseenko¹ ; Vahid Kheirollahi¹ ; Stijn De Langhe² ; Slaven Crnkovic³ ; Grazyna Kwapiszewska³ ; Djuro Kosanovic¹ ; Felix Schwind¹ ; Ralph T. Schermuly¹ ; Ingrid Henneke¹ ; BreAnne MacKenzie¹ ; Jennifer Quantius¹ ; Susanne Herold¹ ; Aglaia Ntokou¹ ; ⁴ ; Katrin Ahlbrecht¹ ; ⁴ ; Rory E. Morty¹ ; ⁴ ; Andreas Gü ; nther¹ ; Werner Seeger¹ ; ⁴ ; Saverio Bellusci¹ ; ⁵ ; ⁶ ; ^{saverio.bellusci@innere.med.uni-giessen.de}
• 刊名：Cell Stem Cell
• 出版年：2017
• 出版时间：2 February 2017
• 年：2017
• 卷：20
• 期：2
• 页码：261-273.e3
• 全文大小：5356 K
• 卷排序：20

文摘

Fate mapping was used to investigate the origin and fate of activated myofibroblasts Lipofibroblasts are precursors for activated myofibroblasts in lung fibrosis Activated myofibroblasts dedifferentiate to lipofibroblasts after recovery PPARγ activation inhibits lipofibroblast-to-myofibroblast transdifferentiation