Investigating placebo effects in irritable bowel syndrome: A novel research design

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• 作者：Lisa A. Conboy ; Rachel H. Wasserman ; Eric E. Jacobson ; Roger B. Davis ; Anna T.R. Legedza ; Min Park ; Andrea L. Rivers ; Elizabeth B. Morey ; Bong Hyun Nam ; Louis Lasagna ; Irving Kirsch ; Anthony J. Lembo
• 关键词：Placebo effect ; Randomized clinical trial ; Research methodology ; Irritable bowel syndrome ; Placebo run-in ; Patient– ; practitioner relationship ; Qualitative methods
• 刊名：Contemporary Clinical Trials
• 出版年：2006
• 出版时间：April 2006
• 年：2006
• 卷：27
• 期：2
• 页码：123-134
• 全文大小：165 K

文摘

Little is known about placebo effects with scientific precision. Poor methodology has confounded our understanding of the magnitude and even the existence of the placebo effect. Investigating placebo effects presents special research challenges including: the design of appropriate controls for studying placebo effects including separating such effects from natural history and regression to the mean, the need for large sample sizes to capture expected small effects, and the need to understand such potential effects from a patient's perspective. This article summarizes the methodology of an ongoing NIH-funded randomized controlled trial aimed at investigating whether the placebo effect in irritable bowel syndrome (IBS) exists and whether the magnitude of such an effect can be manipulated to vary in a manner analogous to “dose dependence.” The trial also uses an innovative combination of quantitative and qualitative methods.