The shedding-derived soluble receptor for advanced glycation endproducts sustains inflammation during acute Pseudomonas aeruginosa lung infection

详细信息    查看全文

• 作者：Antonella Antonelli^a ; ¹ ; ² ; Stefania Di Maggio^b ; ² ; Joanna Rejman^c ; Francesca Sanvito^d ; Alice Rossi^e ; Alessandro Catucci^a ; Andrea Gorzanelli^a ; Alessandra Bragonzi^e ; Marco E. Bianchi^a ; ^f ; ^{bianchi.marco@hsr.it} ; Angela Raucci^a ; ³ ; ^{arau74@yahoo.it} ; ^{araucci@ccfm.it}
• 关键词：RAGE shedding ; Soluble RAGE ; Inflammation ; P. aeruginosa ; Pneumoniae
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1861
• 期：2
• 页码：354-364
• 全文大小：1555 K
• 卷排序：1861

文摘

P. aeruginosa inhibits FL-RAGE shedding and reduces soluble cRAGE levels. Levels of cRAGE sustains P. aeruginosa acute pneumonia. RAGE deficiency facilitates pulmonary P. aeruginosa clearance and inflammation. FL-RAGE shedding may determine the progression of inflammatory lung diseases.