Design and synthesis of 4″,6″-unsaturated cyclic ADP-carbocyclic ribose as a Ca²⁺-mobilizing agent

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• 作者：Takashi Kudoh ; Karin Weber ; Andreas H. Guse ; Barry V.L. Potter ; Minako Hashii ; Haruhiro Higashida ; Mitsuhiro Arisawa ; Akira Matsuda ; Satoshi Shuto
• 关键词：Screen for child anxiety related emotional disorders ; Anxiety disorder ; Psychometrics ; Children ; China
• 刊名：Tetrahedron Letters
• 出版年：2008
• 出版时间：16 June 2008
• 年：2008
• 卷：49
• 期：25
• 页码：3976-3979
• 全文大小：185 K

文摘

4″,6″-Didehydro-cADPcR (3), an unsaturated carbocyclic ribose analog of a Ca²⁺-mobilizing second messenger cyclic ADP-ribose (cADPR), was designed and successfully synthesized using a key intramolecular condensation reaction forming the 18-membered pyrophosphate ring structure with a S-phenyl phosphorothioate-type substrate. Biological evaluation showed that 4″,6″-didehydro-cADPcR is a potent Ca²⁺-mobilizing agent in T cells.