Combined venomics, venom gland transcriptomics, bioactivities, and antivenomics of two Bothrops jararaca populations from geographic isolated regions within the Brazilian Atlantic rainforest
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- 作者：Larissa Gonç ; alves-Machadoa ; b ; c ; 1 ; Davinia Plac ; 1 ; dpla@ibv.csic.es" class="auth_mail" title="E-mail the corresponding author ; Libia Sanzc ; Roberta Jeane B. Jorged ; Moema Leitã ; o-De-Araú ; joe ; Maria Lú ; cia M. Alvese ; Diego Janisch Alvaresf ; Joari De Mirandag ; Jenifer Nowatzkig ; Karen de Morais-Zanih ; Wilson Fernandesh ; Anita Mitico Tanaka-Azevedoh ; Juliá ; n Ferná ; ndezi ; Russolina B. Zingalia ; b ; lzingali@bioqmed.ufrj.br" class="auth_mail" title="E-mail the corresponding author ; José ; Marí ; a Gutié ; rrezi ; Carlos Corrê ; a-Nettoa ; b ; j ; netto@bioqmed.ufrj.br" class="auth_mail" title="E-mail the corresponding author ; Juan J. Calvetec ; jcalvete@ibv.csic.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Snake venom proteomics ; Venom gland transcriptomics ; Antivenomics ; Geographic venom variation ; Bothrops jararaca
- 刊名：Journal of Proteomics
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：135
- 期：Complete
- 页码：73-89
- 全文大小：3003 K
文摘
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Toxin profile and geographic variability of B. jararaca venom were investigated.
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SE and S B. jararaca populations exhibit distinct venom proteomes and bioactivities.
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Post-transcriptional and ontogenetic regulation underlies geographic venom variation.
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Population markers suggest that B. insularis stem in the SE B. jararaca phylogroup.
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Bothropic antivenoms exhibit paraspecificity against SE and S B. jararaca venoms.