How Dextran Sulfate Affects C1-inhibitor Activity: A Model for Polysaccharide Potentiation

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• 作者：Madelon Dijk¹ ; Jolande Holkers² ; Patrick Voskamp¹ ; Bruno M. Giannetti² ; Willem-Jan Waterreus¹ ; Harrie A. van Veen² ; ^{h.vanveen@pharming.com} ; Navraj S. Pannu¹ ; ³ ; ^{raj@chem.leidenuniv.nl}
• 关键词：serine protease inhibitor ; C1-inhibitor ; polysaccharide potentiation ; complement system ; contact system
• 刊名：Structure
• 出版年：2016
• 出版时间：6 December 2016
• 年：2016
• 卷：24
• 期：12
• 页码：2182-2189
• 全文大小：2359 K
• 卷排序：24

文摘

Crystal structure of active C1-inhibitor by itself and with dextran sulfate Dextran sulfate binds to C1-inhibitor's F1 helix with no allosteric change We show low-affinity binding of dextran sulfate to multiple C1-inhibitor molecules We propose that polyanions link C1-inhibitor to protease's autolysis loop