An analogue of atrial natriuretic peptide (C-ANP4-23) modulates glucose metabolism in human differentiated adipocytes
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- 作者：Francisco Javier Ruiz-Ojedaa ; b ; c ; Concepció ; n Marí ; a Aguileraa ; b ; c ; d ; Azahara Iris Rupé ; reza ; b ; Á ; ngel Gila ; b ; c ; d ; Carolina Gomez-Llorentea ; b ; c ; d ; gomezll@ugr.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Obesity ; Adipocytes ; Natriuretic peptide ; Natriuretic peptide receptor 3
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：431
- 期：Complete
- 页码：101-108
- 全文大小：810 K
文摘
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The synthetic ligand C-ANP4-23 increases the intracellular cAMP levels in human differentiated adipocytes.
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C-ANP4-23 up-regulates the gene and protein expression of GLUT4 and enhances glucose uptake, through AMPK activation.
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C-ANP4-23 enhances glucose metabolism and might contribute to the development of new therapies for metabolic diseases.