Sox2 Suppresses Gastric Tumorigenesis in Mice
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- 作者：Abby Sarkar1 ; 2 ; 3 ; 4 ; Aaron J. Huebner1 ; 2 ; 3 ; 4 ; Rita Sulahian3 ; 5 ; 6 ; Anthony Anselmo2 ; Xinsen Xu5 ; 6 ; Kyle Flattery1 ; 2 ; 3 ; 4 ; Niyati Desai7 ; Carlos Sebastian1 ; Mary Anna Yram1 ; 2 ; 3 ; 4 ; Katrin Arnold1 ; 2 ; 3 ; 4 ; Miguel Rivera7 ; Raul Mostoslavsky1 ; Roderick Bronson8 ; Adam J. Bass5 ; 6 ; Ruslan Sadreyev2 ; Ramesh A. Shivdasani3 ; 5 ; 6 ; Konrad Hochedlinger1 ; 2 ; 3 ; 4 ; khochedlinger@mgh.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：16 August 2016
- 年：2016
- 卷：16
- 期：7
- 页码：1929-1941
- 全文大小：6918 K
文摘
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Sox2 targets epithelial, developmental, and cancer genes in gastric progenitors
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Sox2 is dispensable for gastric stem cell self-renewal and epithelial homeostasis
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Sox2+ cells are potent cells of origin in Wnt-driven adenoma model
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Sox2 acts as a tumor suppressor by modulating Wnt-related and intestinal genes