Chemical basis for the disparate neuroprotective effects of the anthocyanins, callistephin and kuromanin, against nitrosative stress

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• 作者：Aimee N. Winter^a ; Erika K. Ross^a ; Sonia Khatter^a ; Keith Miller^b ; Daniel A. Linseman^a ; ^c ; ^d ; ^{Daniel.Linseman@du.edu}
• 关键词：Anthocyanins ; Neuroprotection ; Neurodegeneration ; Nitrosative stress ; Nitric Oxide ; Excitotoxicity
• 刊名：Free Radical Biology and Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：103
• 期：Complete
• 页码：23-34
• 全文大小：1671 K
• 卷排序：103

文摘

Anthocyanins are polyphenolic compounds with neuroprotective properties. Distinct anthocyanins display opposing neuroprotective effects against nitric oxide. Protection from nitric oxide relies on catechol-dependent superoxide generation. Catecholicanthocyanins may be effective therapeutic agents for neurodegeneration.