Recent advances in alveolar biology: Some new looks at the alveolar interface

详细信息    查看全文

• 作者：Fred Possmayer ; Stephen B. Hall ; Thomas Haller ; Nils O. Petersen ; Yi Y. Zuo ; Jorge Bernardino de la Serna ; Anthony D. Postle ; Ruud A.W. Veldhuizen ; S ; ra Orgeig
• 关键词：Pulmonary surfactant ; X-ray diffraction ; Fluorescence microscopy ; Mass spectroscopy ; Phospholipid metabolism ; Acute respiratory distress
• 刊名：Respiratory Physiology & Neurobiology
• 出版年：2010
• 出版时间：31 August 2010
• 年：2010
• 卷：173
• 期：Supplement 1
• 页码：S55-S64
• 全文大小：999 K

文摘

This article examines the manner in which some new methodologies and novel concepts have contributed to our understanding of how pulmonary surfactant reduces alveolar surface tension. Investigations utilizing small angle X-ray diffraction, inverted interface fluorescence microscopy, time of flight-secondary ion mass spectroscopy, atomic force microscopy, two-photon fluorescence microscopy and electrospray mass spectroscopy are highlighted and a new model of ventilation-induced acute lung injury described. This contribution attempts to emphasize how these new approaches have resulted in a fuller appreciation of events presumably occurring at the alveolar interface.