Impact of preformed and de novo anti-HLA DP antibodies in renal allograft survival
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- 作者：Dolores Redondo-Pachó ; na ; Julio Pascuala ; julpascual@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Marí ; a J. Pé ; rez-Sá ; eza ; Carmen Garcí ; ab ; Juan José ; Herná ; ndezb ; Javier Gimenoc ; Marisa Mira ; Marta Crespoa
- 关键词：Renal transplant ; HLA-DP antibodies ; Graft survival
- 刊名：Transplant Immunology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：34
- 期：Complete
- 页码：1-7
- 全文大小：654 K
文摘
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The influence of HLA DP antibodies detected by Luminex® on short and long-term graft survival is not well-known.
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10% of kidney transplant recipients show anti-HLA DP antibodies in single antigen studies, both pre- and posttransplantation.
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The presence of DSA is associated with a negative impact on graft survival. However, the presence of HLA DP antibodies does not modify this impact.
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In selected cases of humoral rejection with undetected HLA A, B, DR or DQ DSA, HLA DP antibodies, as well as other non-HLA antibodies, should be assessed.
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Larger studies with kidney transplant donors well typed for HLA DP are needed to confirm our results.