The influence of HLA DP antibodies detected by Luminex® on short and long-term graft survival is not well-known.
10% of kidney transplant recipients show anti-HLA DP antibodies in single antigen studies, both pre- and posttransplantation.
The presence of DSA is associated with a negative impact on graft survival. However, the presence of HLA DP antibodies does not modify this impact.
In selected cases of humoral rejection with undetected HLA A, B, DR or DQ DSA, HLA DP antibodies, as well as other non-HLA antibodies, should be assessed.
Larger studies with kidney transplant donors well typed for HLA DP are needed to confirm our results.