High levels of Anti-GAD65 and Anti-Ro52 autoantibodies in a patient with major depressive disorder showing psychomotor disturbance

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• 作者：Kathryn H. Ching ; Peter D. Burbelo ; Paul J. Carlson ; Wayne C. Drevets ; Michael J. Iadarola
• 关键词：GAD65 ; Ro52 ; Depression ; Autoimmunity ; Psychomotor disturbance
• 刊名：Journal of Neuroimmunology
• 出版年：2010
• 出版时间：May 2010
• 年：2010
• 卷：222
• 期：1-2
• 页码：87-89
• 全文大小：254 K

文摘

Autoimmune disease and/or autoantibodies have been reported in mood disorder patients. We screened for autoantibodies to glutamic acid decarboxylase (GAD65), thyroid peroxidase (TPO), gastric H+/K+ ATPase (ATP4B), and Ro52 in a psychiatric patient cohort. A 24-year-old woman with major depressive disorder (MDD) with reduced psychomotor activity was identified with unusually high serum GAD65 and Ro52 autoantibody titers. Anti-GAD65 and anti-Ro52 autoantibodies were also elevated in the CSF from this patient. Longitudinal examination revealed a four-fold increase in anti-GAD65 serum antibody titers which correlated with exacerbation of psychomotor symptomatology. These results suggest the possibility that CNS autoimmunity may be responsible for the psychomotor impairment in this MDD patient.