Genetic characterization of influenza viruses from influenza-related hospital admissions in the St. Petersburg and Valencia sites of the Global Influenza Hospital Surveillance Network during the 2013/14 influenza season
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- 作者：F. Xavier Ló ; pez-Labradora ; b ; c ; F.Xavier.Lopez@uv.es" class="auth_mail" title="E-mail the corresponding author ; Angels Natividad-Sanchoa ; angels.natividad@hotmail.co.uk" class="auth_mail" title="E-mail the corresponding author ; Maria Pisarevad ; pisareva@influenza.spb.ru" class="auth_mail" title="E-mail the corresponding author ; Andrey Komissarovd ; komissarov@influenza.spb.ru" class="auth_mail" title="E-mail the corresponding author ; Karina Salvatierraa ; b ; 1 ; kariales@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Artem Fadeevd ; artem.fadeev@influenza.spb.ru" class="auth_mail" title="E-mail the corresponding author ; André ; s Moyab ; andres.moya@uv.es" class="auth_mail" title="E-mail the corresponding author ; Mikhail Grudinind ; grudinin@influenza.spb.ru" class="auth_mail" title="E-mail the corresponding author ; Javier Dí ; ez-Domingoa ; diez_jav@gva.es" class="auth_mail" title="E-mail the corresponding author ; Olga Afanasievad ; olga-afanaseva57@mail.ru" class="auth_mail" title="E-mail the corresponding author ; Nadezhda Konovalovad ; konovalova_nadya@mail.ru" class="auth_mail" title="E-mail the corresponding author ; Anna Somininad ; anna@influenza.spb.ru" class="auth_mail" title="E-mail the corresponding author ; Joan Puig-Barberà ; a ; puig_joa@gva.es" class="auth_mail" title="E-mail the corresponding author ; jpuigb55@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：aHap ; haplotypes spanning either the antigenic sites ; GIHSN ; Global Influenza Hospital Surveillance Network ; HA ; hemagglutinin ; Hap ; full length HA gene haplotypes ; k ; the average number of pairwise differences ; π ; the average number of pairwise differences per site (or nucleotide diversity) ; RT-PCR ; reverse-transcription polymerase chain reaction ; S ; number of segregating sites ; θ ; the heterozygosity per site expected in a population in mutation-drift equilibrium given the observed S value
- 刊名：Journal of Clinical Virology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：84
- 期：Complete
- 页码：32-38
- 全文大小：2399 K
文摘
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Influenza A virus isolates from Valencia and St. Petersburg were analyzed.
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Genetic differences were greater for influenza A(H3N2) than for A(H1N1)pdm09.
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>90% of A(H3N2) viral isolates clustered with the previous season’s dominant clades.
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Pairwise amino acid distances vs. vaccine strains were highest for H3N2 clade 3C.2.
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Influenza A HA sequences and antigenic variants differed between the 2 sites.