Prior infection with influenza virus but not vaccination leaves a long-term immunological imprint that intensifies the protective efficacy of antigenically drifted vaccine strains
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- 作者：Jin Hyang Kima ; Justine Liepkalnsa ; 1 ; Adrian J. Rebera ; Xiuhua Lua ; Nedzad Musica ; Joshy Jacobb ; joshy.jacob@emory.edu" class="auth_mail" title="E-mail the corresponding author ; Suryaprakash Sambharaa ; zao1@cdc.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：HA ; hemagglutinin ; NA ; neuraminidase ; HI ; hemagglutination inhibition ; HAU ; hemagglutination unit ; MN ; microneutralization ; LD50 ; 50% lethal dose ; PFU ; plaque forming unit
- 刊名：Vaccine
- 出版年：2016
- 出版时间：20 January 2016
- 年：2016
- 卷：34
- 期：4
- 页码：495-502
- 全文大小：1161 K
文摘
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Prior influenza infection, but not immunization, intensified the vaccine efficacy of a drift strain.
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Antigenic distances between infecting vs. immunization strains were not a limiting factor for heightened vaccine efficacy.
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Prior infection broadened cross-reactivity of vaccine strains against antigenically further drifted strains.
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The impact of prior infection for enhancing vaccine efficacy was long-lasting.