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• 作者：Kalliopi Vallianatou
• 关键词：Adverse effects ; antagonist ; antipsychotic ; dopamine ; extrapyramidal ; hyperprolactinaemia ; psychosis ; serotonin
• 刊名：Medicine
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：44
• 期：12
• 页码：748-752
• 全文大小：101 K

文摘

Antipsychotics are the mainstay of psychosis treatment. They are also used in the acute and long-term treatment of bipolar disorder, in depression and other conditions. They are classified as first-generation (‘typical’) and second-generation (‘atypical’) antipsychotics based on their ability to cause extrapyramidal symptoms (EPS). Metabolic adverse effects occur mainly with second-generation antipsychotics. Both classes have broadly similar efficacy in controlling the symptoms of psychosis with the exception of clozapine, which is unique in its improved efficacy in treatment-resistant schizophrenia.