Design, synthesis and evaluation of novel 2-amino-3-(naphth-2-yl)propanoic acid derivatives as potent inhibitors of platelet aggregation

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• 作者：Zhouling Xie^a ; Benimana Oscar^a ; Lulu Zhao^a ; Xue Ding^b ; Chen Cao^a ; Sen Feng^a ; Han Li^a ; Chen Pan^a ; Ziyi Bian^a ; Yang Li^a ; Weijun Wang^a ; Yi Kong^b ; ^{yikong668@163.com} ; Zhiyu Li^a ; ^{zhiyuli@cpu.edu.cn}
• 关键词：Antiplatelet aggregation ; GPIIb/IIIa receptor ; Inhibitor ; Naphthalene derivatives ; Antithrombotic activity ; Bleeding risk
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：125
• 期：Complete
• 页码：197-209
• 全文大小：2218 K
• 卷排序：125

文摘

LX5 was identified based on an identified antiplatelet aggregation agent LX2421. LX14 shows comparable ability as Tirofiban in inhibiting platelet aggregation and GPIIb/IIIa receptor. LX14 has less bleeding risk in comparison with Tirofiban.