A novel CD14high CD16high subset of peritoneal macrophages from cirrhotic patients is associated to an increased response to LPS
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- 作者：Antonio José ; Ruiz-Alcaraza ; 1 ; Ana Tapia-Abellá ; na ; 1 ; Marí ; a Dolores Ferná ; ndez-Ferná ; ndeza ; Marí ; a Tristá ; n-Manzanoa ; Trinidad Herná ; ndez-Casellesa ; Eduardo Sá ; nchez-Velascob ; Manuel Miras-Ló ; pezb ; Marí ; a Martí ; nez-Esparzaa ; 1 ; maria@um.es" class="auth_mail" title="E-mail the corresponding author ; Pilar Garcí ; a-Peñ ; arrubiaa ; 1 ; pigarcia@um.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：AF ; ascites fluid ; CCL2 ; chemokine (CC motif) ligand 2 ; ERK ; extracellular signal-regulated kinase ; GM-CSF ; granulocyte-macrophage colony-stimulating factor ; LPS ; lipopolysaccharide ; M-DM ; monocyte-derived macrophages ; MAPK ; mitogen-activated protein kinase ; MIP ; macrophage inflammatory protein ; NFкB ; nuclear factor kappa-light-chain-enhancer of activated B cells ; PKB ; protein kinase B ; PMN ; polymorphonuclear ; SBP ; spontaneous bacterial peritonitis ; TGF-β ; transforming growth factor beta ; TLR-4
- 刊名：Molecular Immunology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：72
- 期：Complete
- 页码：28-36
- 全文大小：2299 K
文摘
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First description of a CD14highCD16high M-DM subset in ascites fluid of cirrhotic patients.
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Basal hyperactivation of ERK and c-Jun correlates with CD14CD16 high expressing M-DM subsets.
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Basal hyperactivation of PKB correlates with CD16 low expressing M-DM.
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CD14 high-expressing subsets may be responsible for the enhanced response to LPS.
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Ascites M-DM produce higher amounts of IL-6, IL-10 and TNF-α, while lower levels of IL-1β and IL-12.