Screening of pharmacologic adulterant classes in herbal formulations using voltammetry of microparticles

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• 作者：Antonio Domé ; nech-Carbó ; ^a ; ^{antonio.domenech@uv.es} ; Mariele Martini^b ; Leandro Machado de Carvalho^b ; Carine Viana^b ; Mar&#237 ; a Teresa Domé ; nech-Carbó ; ^c ; Miguel Silva^c
• 关键词：Adulterants ; Herbal formulations ; Screening ; Voltammetry of microparticles ; AFM
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2013
• 出版时间：23 February, 2013
• 年：2013
• 卷：74
• 期：Complete
• 页码：194-204
• 全文大小：1575 K

文摘

A solid state electrochemical method for screening different families of adulterant chemicals illegally added to commercial phytotherapuetic formulations is described. The proposed method, based on the voltammetry of microparticles approach, permits a fast and sensitive way to distinguish between anorexics (amfepramone, fenproporex, sibutramine), benzozodiazepinic anxiolytics (clonazepam, flurazepam, alprazolam, midazolam, medazepam, chlordiazepoxide, diazepam), antidepressants (bupropione, fluoxetine, sertraline, paroxetine), diuretics (hydrochlorothiazide, furosemide, chlortalidone, amiloride, spironolactone), and hypoglycemics (glimepiride, chlorpropamide, glibenclamide) based on characteristic voltammetric signals recorded on solid micro- or nanosamples attached to graphite electrodes immersed into aqueous electrolytes.