Characterisation and comparative analysis of MHC-DPA1 exon 2 in the owl monkey (Aotus nancymaae)

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• 作者：Carlos F. Suá ; rez M. ; Manuel A. Patarroyo ; Manuel E. Patarroyo
• 关键词：Animal model ; MHC class II molecule ; Molecular evolution ; New world monkeys ; Platyrrhini
• 刊名：Gene
• 出版年：2011
• 出版时间：1 January 2011
• 年：2011
• 卷：470
• 期：1-2
• 页码：37-45
• 全文大小：1673 K

文摘

The Aotus nancymaae (owl monkey) is an important animal model in biomedical research, particularly for the preclinical evaluation of vaccine candidates against Plasmodium falciparum and Plasmodium vivax, which require a precisely typed major histocompatibility complex. The exon 2 from A. nancymaae MHC-DPA1 gene was characterised in order to infer its allelic diversity and evolutionary history. Aona-DPA1 shows no polymorphism and is related to other primate DPA alleles (including Catarrhini and Platyrrhini), constituting an ancient trans-specific and strongly supported lineage with different variability and selective patterns when compared to other primate–MHC-DPA1 lineages. A. nancymaae monkeys have thus a smaller MHC-DP polymorphism than MHC-DQ or MHC-DR.