Persistence and immunogenicity of chemically attenuated blood stage Plasmodium falciparum in Aotus monkeys
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- 作者：Sai Lata Dea ; 1 ; Danielle I. Stanisica ; 1 ; Karin van Bredab ; Bernadette Belletea ; Ivor Harrisb ; Fiona McCallumb ; Michael D. Edsteinb ; Michael F Gooda ; michael.good@griffith.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chemically attenuated parasites ; Tafuramycin-A ; Whole parasite blood stage vaccine ; Plasmodium falciparum FVO ; Malaria ; Aotus monkeys
- 刊名：International Journal for Parasitology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：46
- 期：9
- 页码：581-591
- 全文大小：3707 K
文摘
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Evaluation of persistence and immunogenicity of chemically attenuated Plasmodium falciparum (CAPs) in non-human primates.
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Parasite DNA was detected in the blood of the CAP-inoculated monkeys for up to 8 days.
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CD8+ T cell response to cultured live P. falciparum was seen in the CAP-inoculated monkeys.
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Plasmodium falciparum CAPs can induce T cell responses and as such supports undertaking a human study.