Complete genome sequence of sequential Pandoraea apista isolates from the same cystic fibrosis patient supports a model of chronic colonization with in vivo strain evolution over time
Complete genome sequence was obtained for 3 P. apista isolates. P. apista genomes demonstrate several novel loci. Genome comparison indicates chronic colonization in the cystic fibrosis lung niche. These bacteria accumulate approximately 100 mutations per year in vivo.