Marine n-3 fatty acids are incorporated into atrial tissue but do not correlate with postoperative atrial fibrillation in cardiac surgery

详细信息    查看全文

• 作者：J. Gu^a ; ^b ; ^c ; ^d ; Sø ; ren Lundbye-Christensen^d ; ^f ; Rikke B. Eschen^e ; Annette Andreasen^e ; Jan J. Andreasen^a ; ^b ; ^d ; ^jja@rn.dk
• 关键词：Postoperative atrial fibrillation ; Cardiac surgery ; Marine fatty acids ; Atrial tissue ; Plasma phospholipids
• 刊名：Vascular Pharmacology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：87
• 期：Complete
• 页码：70-75
• 全文大小：441 K
• 卷排序：87

文摘

Postoperative new-onset atrial fibrillation (POAF) in cardiac surgery is associated with increased morbidity and mortality. Because n-3 polyunsaturated fatty acids (n-3 PUFA) have an antiarrhythmic effect, we hypothesized that a high content of marine n-3 PUFA in the atrial wall was associated with a reduced risk of POAF.DesignVenous blood and tissue from the right atrial appendage were obtained from 50 patients undergoing elective cardiac surgery. We determined the content of marine n-3 PUFA in atrial tissue and in plasma phospholipids using gas chromatography.ResultsThe mean age of the patients (results available from 49 patients) was 66.0 ± 10.4 years, and 22, 14, 10 and 3 patients underwent coronary artery bypass surgery, valve, combined or other cardiac surgery, respectively. Eighteen patients (36.7%) developed POAF. Concentrations of n-3 PUFA in the atrial wall and in plasma phospholipids did not predict the development of POAF, but there were significant correlations between marine n-3 PUFA in atrial tissue and plasma.ConclusionLevels of marine n-3 PUFA in the atrial wall was not associated with the risk of POAF following cardiac surgery, despite significant correlations of marine n-3 PUFA in the atrium and in plasma phospholipids.