Skin autofluorescence (a marker for advanced glycation end products) and erectile dysfunction in diabetes

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• 作者：Youssef Kouidrat^a ; ^b ; ^{youssef.kouidrat@gmail.com} ; Ahmad Zaitouni^b ; Ali Amad^c ; Momar Diouf^b ; Rachel Desailloud^b ; Gwenole Loas^d ; Jean-Daniel Lalau^b
• 关键词：Diabetes ; Advanced glycation end product ; Skin autofluorescence ; Erectile dysfunction ; Microangiopathy ; Cardiovascular risk
• 刊名：Journal of Diabetes and its Complications
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：31
• 期：1
• 页码：108-113
• 全文大小：318 K
• 卷排序：31

文摘

Although diabetes-related erectile dysfunction (ED) has many etiological factors, little is known about the putative pathophysiological role of advanced glycation end products (AGEs). Skin autofluorescence is a noninvasive marker of AGEs. Recent studies have evidenced a relationship between skin autofluorescence and several complications of diabetes. We hypothesized that AGEs (assessed by skin autofluorescence) are associated with ED in diabetes patients.MethodsBetween March 2014 and April 2015, 42 patients with type 1 diabetes (T1D) and 44 patients with type 2 diabetes (T2D) were consecutively enrolled in a descriptive, cross-sectional study and compared to 54 healthy controls. ED was evaluated via the 5-item version of the International Index of Erectile Function (IIEF-5). Skin autofluorescence was measured on the volar aspect of the arm with an AGE-Reader.ResultsPatients with diabetes had a mean ± standard deviation age of 50 ± 15 and a mean duration of diabetes of 16 ± 12 years. Skin autofluorescence was strongly and significantly correlated with the IIEF-5 score in the T1D subgroup (r = − 0.52; P = 0.004), the T2D subgroup (r = − 0.32; P < 0.03) and in the whole group of diabetic patients (r = − 0.49; P < 0.0001). In multivariate analyses that controlled for potentially confounding clinical and biochemical factors, only skin autofluorescence was still significantly correlated with the IIEF-5 score (P < 0.0001). A receiver operating characteristic analysis revealed that a skin autofluorescence value ≥ 3.2 AU determined severe ED with a sensitivity of 60% and a specificity of 87% in diabetic patients.ConclusionSkin autofluorescence is significantly associated with ED in diabetes, independently of classical confounding factors.