Synthesis of copper and zinc 2-(pyridin-2-yl)imidazo[1,2-a]pyridine complexes and their potential anticancer activity

详细信息    查看全文

• 作者：Jean Dam^a ; ^{Jean.Dam@students.wits.ac.za} ; Zeenat Ismail^b ; ^{Zeenat.Ismail@students.wits.ac.za} ; Taurai Kurebwa^b ; ^{t.Kurebwa@gmail.com} ; Nadia Gangat^b ; ^{Nadia.Gangat@students.wits.ac.za} ; Leonie Harmse^b ; ^{Leonie.Harmse@wits.ac.za} ; Helder M. Marques^a ; ^{Helder.Marques@wits.ac.za} ; Andreas Lemmerer^a ; ^{Andreas.Lemmerer@wits.ac.za} ; Moira L. Bode^a ; ^{Moira.Bode@wits.ac.za} ; Charles B. de Koning^a ; ^{Charles.deKoning@wits.ac.za}
• 关键词：Copper and zinc imidazo[1 ; 2-a]pyridines ; Multicomponent coupling reactions ; Breast cancer (MCF-7 and MDA-MB-231) ; Leukemia (K562 and HL-60) and colorectal cancer (HT-29) ; Apoptosis ; Necrosis and paraptosis ; Fluorescence microscopy
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：27 January 2017
• 年：2017
• 卷：126
• 期：Complete
• 页码：353-368
• 全文大小：2242 K
• 卷排序：126

文摘

Copper and zinc 2-pyridin-2-yl-imidazo[1,2-a]pyridine complexes synthesized. Good anticancer activity of copper-imidazo[1,2-a]pyridines against 5 cancer cell lines. Fluorescence microscopy to evaluate morphological changes during cell death.