Design, synthesis and cytotoxicity studies of novel pyrazolo[1, 5-a]pyridine derivatives

详细信息    查看全文

• 作者：Chitrakar Ravi^a ; ¹ ; Arem Qayum^b ; ¹ ; Darapaneni Chandra Mohan^a ; Shashank K. Singh^b ; ^{sksingh@iiim.ac.in} ; Subbarayappa Adimurthy^a ; ^{adimurthy@csmcri.org}
• 关键词：Pyrazolo[1 ; 5&ndash ; a]pyridines ; Cytotoxicity ; MCF-7 cells ; Growth inhibition ; SRB assay
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：27 January 2017
• 年：2017
• 卷：126
• 期：Complete
• 页码：277-285
• 全文大小：1108 K
• 卷排序：126

文摘

This work highlights the synthesis of substituted pyrazolo[1,5-a]pyridine derivatives as anticancer agents. In vitro screening of target pyrazolo[1, 5-a]pyridines against various human cancer cell lines. Determination of IC50 against various human cancer cell lines. Pyrazolo[1, 5-a]pyridines are active anticancer, antimicrobial, antiviral, antipsychotic, etc.