Electroanalytical study of the antidepressant sertraline

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• 作者：Henri P.A. Nouws ; Cristina Delerue-Matos ; Aquiles A. Barros and Jos&#xe9 ; A. Rodrigues
• 关键词：Flow injection ; Hanging mercury drop electrode ; Adsorptive stripping voltammetry ; Sertraline ; SSRI
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2005
• 出版时间：2005
• 年：2005
• 卷：39
• 期：1-2
• 页码：290-293
• 全文大小：83 K

文摘

A flow injection square wave cathodic stripping voltammetric method has been developed for the determination of sertraline in a pharmaceutical preparation. The method shows linearity between peak current intensity and sertraline concentration for the interval between 0.20 × 10⁻⁶ and 1.20 × 10⁻⁶ mol L⁻¹. Limits of detection and quantification were found to be 1.5 × 10⁻⁷ and 5.0 × 10⁻⁷ mol L⁻¹, respectively. Up to 70 samples per hour can be analysed with a good precision (R.S.D. = 2.5 % ). The proposed method was successfully applied to the determination of sertraline in a commercial product. In the voltammetric determination of sertraline in flow, a high sample rate is obtained at reduced costs, opening the possibility to compete with the chromatographic methods generally used for this analysis.