Electroanalytical determination of paroxetine in pharmaceuticals

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• 作者：Henri P.A. Nouws ; Cristina Delerue-Matos ; Aquiles A. Barros and Jos&#xe9 ; A. Rodrigues
• 关键词：Paroxetine ; Square-wave adsorptive-stripping voltammetry ; Flow-injection analysis ; Electrochemical detection ; SSRI
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2006
• 出版时间：26 September 2006
• 年：2006
• 卷：42
• 期：3
• 页码：341-346
• 全文大小：155 K

文摘

Electroanalytical methods based on square-wave adsorptive-stripping voltammetry (SWAdSV) and flow-injection analysis with SWAdSV detection (FIA-SWAdSV) were developed for the determination of paroxetine (PRX). The methods were based on the reduction of PRX at a mercury drop electrode at −1.55 V versus Ag/AgCl, in a borate buffer of pH 8.8, and the possibility of accumulating the compound at the electrode surface. Because the presence of dissolved oxygen did not interfere significantly with the analysis, it was also possible to determine PRX using FIA-SWAdSV. This method enables analysis of up to 120 samples per hour at reduced costs. Both methods developed were validated and successfully applied to the quantification of PRX in pharmaceutical products.