Targeting brain and peripheral plasticity of the lipidome in acute kainic acid-induced epileptic seizures in mice via quantitative mass spectrometry

详细信息    查看全文

• 作者：Raissa Lerner¹ ; Julia Post¹ ; Sebastian Loch ; Beat Lutz ; Laura Bindila ; ^{bindila@uni-mainz.de}
• 关键词：2-AG ; 2-arachidonyl glycerol ; 5(S)-HETE ; 5S-hydroxyeicosatetraenoic acid ; 8(S)-HETE ; 8(S)-hydroxyeicosatetraenoic acid ; 12(S)-HETE ; 12(S)-hydroxyeicosatetraenoic acid ; 15(S)-HETE ; 15(S)-hydroxyeicosatetraenoic acid ; 19(S)-HETE ; 19S-hydroxyeicosatetraenoic acid ; 20(S)-HETE ; 20-hydroxyeicosatetraenoic acid ; AA ; arachidonic acid ; ACN ; acetonitrile ; AEA ; arachidonoyl ethanolamide ; BBB ; blood brain barrier ; BHT ; butylhydroxytoluene ; CB1R ; cannabinoid receptor 1 ; cCTX ; cerebral cortex ; CER ; cerebellum
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1862
• 期：2
• 页码：255-267
• 全文大小：1924 K
• 卷排序：1862

文摘

Changes of the phospholipid, endocannabinoid, endocannabinoid-like molecule, arachidonic acid and eicosanoid levels, respectively, occur in brain and periphery of mice with kainic acid induced acute epileptic seizures. Hippocampus, hypothalamus, cerebellum, striatum, cortex and thalamus of acute epileptic seizure mice exhibit distinct and specific lipid changes. Lipid alteration occurs, distinctly, in lungs and hearts of mice with kainic acid induced epileptic seizures. Lipid signatures of kainic acid induced acute epileptic seizure in mouse plasma reflect dysregulation of the endocannabinoid system, inflammatory processes and phospholipid metabolism.