Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain
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- 作者：Emma Leishmana ; Ken Mackiea ; b ; Serge Luquetc ; Heather B. Bradshawa ; hbbradsh@indiana.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：2-AG ; 2-arachidonyl glycerol ; 2-LG ; 2-linoleoyl glycerol ; ABHD4 ; α/β-hydrolase domain 4 ; AEA ; N-arachidonoyl ethanolamine (anandamide) ; A-Taur ; N-arachidonoyl taurine ; CER ; cerebellum ; COX ; cyclooxygenase ; CTX ; cortex ; DEA ; N-docosahexaenoyl ethanolamine ; eCB ; endogenous cannabinoid ; FAAH ; fatty acid amide hydrolase ; GABA ; gamma-amino butyric acid ; GDE1 ; glycerophosphodiesterase 1 ; HIPP ; hippocampus ; HYP ; hypothalamus ; KO ; knockout ; LEA ; N-linoleoyl ethanolamine ; MAGL ; monoacylglycerol lipase ; M
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：1861
- 期：6
- 页码：491-500
- 全文大小：479 K
文摘
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NAPE-PLD KO mice show a significant reduction in brain levels of Anandamide.
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Modifying NAPE-PLD has broader effects on the lipidome than previously recognized.
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NAPE-PLD KO has brain region-dependent effects on arachidonic acid derivatives.
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Increased prostaglandin levels illustrate a dramatic shift in arachidonic acid metabolism.