A study of cannabinoid-1 receptors during the early phase of excitotoxic damage to rat spinal locomotor networks in vitro
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- 作者：Priyadharishini Veeraraghavan bvraghav@sissa.it" class="auth_mail" title="E-mail the corresponding author ; Ana Dekanic&dagger ; ; adekanic@irb.hr" class="auth_mail" title="E-mail the corresponding author ; Andrea Nistri ; nistri@sissa.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：2-AG ; 2-arachidonoylglycerol ; 5-HT ; 5-hydroxytryptamine or serotonin ; AEA ; N-arachidonoylethanolamine or anandamide ; cAMP ; cyclic adenosine monophosphate ; CB1R ; cannabinoid receptor-1 ; DAPI ; 4 ; 6-diamidino-2-phenylindole ; DR ; dorsal root ; FL ; fictive locomotion ; Frsk ; forskolin ; GABA ; γ-aminobutyric acid ; KA ; kainate ; NMDA ; N-methyl-d-aspartate ; ROI ; regions of interest ; SCI ; spinal cord injury ; SEM ; standard error mean ; VR ; ventral root
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：333
- 期：Complete
- 页码：214-228
- 全文大小：3838 K
文摘
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Any early role of cannabinoid receptors in neuroprotection after spinal cord injury is unclear.
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Cannabinoid-1 receptor expression and activity persisted 24 h after transient excitotoxic stress.
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Anandamide, its uptake blocker or 2-arachidonoylglycerol could not prevent locomotor pattern damage.
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Although anandamide significantly protected central region neurons, it did not protect motoneurons.
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The cannabinoid receptor blocker AM251 applied after kainate potentiated structural and functional deficit.