Tales from the dark side: Do neuromodulators of drug withdrawal require changes in endocannabinoid tone?
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- 作者：Erik B. Olesona ; b ; Roger Cachopea ; Aurelie Fitoussia ; Joseph F. Cheera ; jchee001@umaryland.edu" class="auth_mail
- 关键词：2AG ; 2-arachidonoyl-glycerol ; DA ; dopamine ; DG ; Diacylglycerol ; DGL ; diacylglycerol lipase ; GABA ; gamma amino butyric acid ; Glu ; glutamate ; mGluR ; metabotropic glutamate receptor ; NMDAR ; N-methyl-D-Aspartate Receptor ; PLC ; phospholipase C
- 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
- 出版年：3 July 2014
- 年：2014
- 卷：52
- 期：Complete
- 页码：17-23
- 全文大小：549 K
文摘
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All drugs of abuse produce some form of withdrawal.
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Withdrawal-associated stimuli begin to motivate drug seeking.
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Conditioned withdrawal shares parallels with conditioned avoidance.
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Subsecond dopamine release is involved in conditioned avoidance.
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Endocannabinoids have the potential to modulate subsecond dopamine release during drug withdrawal.