Luteinizing hormone/chorionic gonadotrophin receptor overexpressed in granulosa cells from polycystic ovary syndrome ovaries is functionally active
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- 作者：Venkateswarlu Kanamarlapudia ; k.venkateswarlu@swansea.ac.uk" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Uma D. Gordonb ; André ; s Ló ; pez Bernalc
- 关键词：ARF6 ; cAMP ; human granulosa cells ; LHCGR ; PCOS
- 刊名：Reproductive BioMedicine Online
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：32
- 期：6
- 页码：635-641
- 全文大小：957 K
文摘
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LHCGR expression and activity are increased in GCs from PCOS patients.
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ARF6 small GTPase is highly expressed in PCOS GCs.
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HCG-stimulation increased the levels of active form of ARF6.
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ARF6 activation inhibitors reduced LHCGR internalisation in normal and PCOS GCs.
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HCG-induced HLHCGR internalisation is unaltered in PCOS GCs.