Enterohaemorrhagic E. coli modulates an ARF6:Rab35 signaling axis to prevent recycling endosome maturation during infection
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- 作者：R. Christopher D. Furniss ; Sabrina Slater ; Gad Frankel ; Abigail Clements ; a.clements@imperial.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：ARF ; ADP ribosylation factor ; T3SS ; Type III secretion system ; PM ; plasma membrane ; RE ; recycling endosome ; TfR ; transferrin receptor ; GFP ; green fluorescent protein ; A/E ; attaching and effacing ; E. coli ; Escherichia coli ; OCRL ; oculocerebrorenal syndrome of Lowe ; CCV ; clathrin coated vesicles ; EEA1 ; early endosome antigen 1 ; CLC ; clathrin light chain
- 刊名：Journal of Molecular Biology
- 出版年：2016
- 出版时间：28 August 2016
- 年：2016
- 卷：428
- 期：17
- 页码：3399-3407
- 全文大小：1210 K
文摘
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EHEC delivers effector proteins into host cells to establish infection in the gut
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The effector EspG interacts with GTP-ARF6 confining EspG to recycling endosomes
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During infection EspG interacts preferentially with Rab35, not Rab1
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Spatial restriction of bacterial effectors during infection determines their function