Ral-Arf6 crosstalk regulates Ral dependent exocyst trafficking and anchorage independent growth signalling
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- 作者：Archana Pawara ; Jeremy A. Meierb ; Anwesha Dasguptaa ; Neha Diwanjia ; Neha Deshpandea ; Kritika Saxenaa ; Natasha Buwaa ; Siddhi Inchanalkara ; Martin Alexander Schwartzb ; c ; Nagaraj Balasubramaniana ; nagaraj@iiserpune.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Adhesion ; Ral ; Arf6 ; Exocyst trafficking ; Anchorage independence ; Cancer
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：28
- 期：9
- 页码：1225-1236
- 全文大小：1648 K
文摘
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Ral mediates Arf6 activation downstream of integrins and oncogenic Ras.
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Arf6 mediates Ral-exocyst dependent delivery of raft microdomains.
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Active Ral supports anchorage independent Arf6 activation in bladder cancer T24 cells.
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Ral-Arf6 crosstalk in T24 cells regulates anchorage independent Erk signalling.
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A Ral-RalBP1-ARNO-Arf6 pathway mediates the Ral-Arf6 crosstalk.