ARF6 Is an Actionable Node that Orchestrates Oncogenic GNAQ Signaling in Uveal Melanoma
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- 作者：Jae Hyuk Yoo1 ; 2 ; 17 ; Dallas S. Shi1 ; 3 ; 17 ; Allie H. Grossmann1 ; 4 ; 5 ; 17 ; Lise K. Sorensen1 ; ZongZhong Tong6 ; 7 ; Tara M. Mleynek1 ; Aaron Rogers4 ; Weiquan Zhu1 ; 14 ; Jackson R. Richards1 ; 2 ; Jacob M. Winter1 ; Jie Zhu8 ; Christine Dunn6 ; Ashok Bajji6 ; 9 ; Mark Shenderovich6 ; 10 ; Alan L. Mueller6 ; Scott E. Woodman11 ; J. William Harbour12 ; Kirk R. Thomas1 ; 13 ; Shannon J. Odelberg1 ; 14 ; 15 ; Kirill Ostanin6 ; kostanin@nvgn.com" class="auth_mail" title="E-mail the corresponding author ; Dean Y. Li1 ; 2 ; 3 ; 5 ; 7 ; 14 ; 16 ; dean.li@u2m2.utah.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：13 June 2016
- 年：2016
- 卷：29
- 期：6
- 页码：889-904
- 全文大小：5878 K
文摘
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ARF6 is an immediate downstream effector of an activated GNAQ/GEP100 complex
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ARF6 acts as a node for all downstream signaling pathways induced by oncogenic GNAQ
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Maximal signaling occurs when GNAQ is shuttled to cytoplasmic vesicles
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Targeting nodes such as ARF6 provide an approach for treating recalcitrant cancers