Gene-environment interactions in heavy metal and pesticide carcinogenesis

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• 作者：Shams Tabrez ; Medha Priyadarshini ; Shubha Priyamvada ; Mohd Shahnawaz Khan ; Arivarasu NA ; Syed Kashif Zaidi
• 关键词：Environment ; Gene ; Polymorphism ; Heavy metals ; Pesticides
• 刊名：Mutation Research/Genetic Toxicology and Environmental Mutagenesis
• 出版年：15 January, 2014
• 年：2014
• 卷：760
• 期：Complete
• 页码：1-9
• 全文大小：1670 K

文摘

Cancer is a complex disease involving a sequence of gene-environment interactions. Lifestyle, genetics, dietary factors, and environmental pollutants can increase the risk of cancer. Gene-environment interactions have been studied by a candidate-gene approach focusing on metabolism, DNA repair, and apoptosis. Here, we review the influence of gene-environment interactions in carcinogenesis, with emphasis on heavy metal and pesticide exposures.