Evidence for a role of GABA- and glutamate-gated chloride channels in olfactory memory

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• 作者：Katia Boumghar ; Thomas Couret-Fauvel ; Mikael Garcia ; Catherine Armengaud
• 关键词：Honeybee ; Mushroom bodies ; Olfactory conditioning ; GABA ; Glutamate ; Picrotoxin
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：2012
• 出版时间：November, 2012
• 年：2012
• 卷：103
• 期：1
• 页码：69-75
• 全文大小：401 K

文摘

In the honeybee, we investigated the role of transmissions mediated by GABA-gated chloride channels and glutamate-gated chloride channels (GluCls) of the mushroom bodies (MBs) on olfactory learning using a single-trial olfactory conditioning paradigm. The GABAergic antagonist picrotoxin (PTX) or the GluCl antagonist l-trans-pyrrolidine-2,4-dicarboxylic acid (l-trans-PDC) was injected alone or in combination into the ¦Á-lobes of MBs. PTX impaired early long-term olfactory memory when injected before conditioning or before testing. l-trans-PDC alone induced no significant effect on learning and memory but induced a less specific response to the conditioned odor. When injected before PTX, l-trans-PDC was able to modulate PTX effects. These results emphasize the role of MB GABA-gated chloride channels in consolidation processes and strongly support that GluCls are involved in the perception of the conditioned stimulus.