IL-6 Strikes a Balance in Metabolic Inflammation

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• 作者：Anthony J. Covarrubias¹ ; Tiffany Horng¹ ; ^{thorng@hsph.harvard.edu" class="auth_mail}
• 刊名：Cell Metabolism
• 出版年：3 June 2014
• 年：2014
• 卷：19
• 期：6
• 页码：898-899
• 全文大小：295 K

文摘

Interleukin-6 (IL-6) is a pleiotropic cytokine that exerts either proinflammatory or anti-inflammatory effects and is implicated in diverse settings, including obesity, exercise, arthritis, and colitis. A new study shows that modulation of macrophage activation by IL-6 maintains glucose homeostasis in diet-induced obesity while limiting inflammation in endotoxemia (Mauer et al., 2014).