Antimycotic efficacy of Iranian medicinal plants towards dermatophytes obtained from patients with dermatophytosis

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• 作者：Reza Ali Khosravi^a ; ^{khosravi@ut.ac.ir} ; Hojjatollah Shokri^b ; Zohreh Farahnejat^c ; Reza Chalangari^d ; Martis Katalin^d
• 关键词：Antifungal activity ; Iranian herbal plants ; Artemisia sieberi ; Essential oil ; Dermatophytes
• 刊名：Chinese Journal of Natural Medicines
• 出版年：2013
• 出版时间：January, 2013
• 年：2013
• 卷：11
• 期：1
• 页码：43-48
• 全文大小：521 K

文摘

Aim

Nine plant essential oils (EOs), including those from Artemisia sieberi, Cuminum cyminum, Foeniculum vulgare, Heracleum persicum, Menta spicata, Nigella sativa, Rosmarinus officinalis, Zataria multiflora and Ziziphora clinopodioides, were evaluated for their anti-dermatophytic properties.

Methods

The tested dermatophytes included Trichophyton mentagrophytes (No. 32), T. rubrum (No. 29), Epidermophyton floccosum (No. 19), Microsporum gypseum (No. 11) and M. canis (No. 42). The susceptibility tests of plant oils in terms of minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) were performed by the broth microdilution technique as described by the Clinical Laboratory Standard Institute.

Results

All EOs studied were active against the dermatophytes. The MICs recorded for the plant oils tested ranged from 0.25 to 4 mg¡¤mL^?1. The most significant activity was observed with A. sieberi, showing a lower MIC against dermatophytes than other plant oils (P < 0.05).

Conclusion

Data from this study indicated that several Iranian medicinal plant oils, mainly A. sieberi, are active in vitro against different dermatophyte species, suggesting their potential use for the topical treatment of dermatophytoses.