ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis
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- 作者：Haiquan Lua ; b ; Xinqun Lia ; Yang Lua ; Songbo Qiua ; Zhen Fana ; b ; zfan@mdanderson.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：ASCT2 ; Glutathione ; ROS ; EGFR ; Cetuximab ; HNSCC
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：10 October 2016
- 年：2016
- 卷：381
- 期：1
- 页码：23-30
- 全文大小：2023 K
文摘
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ASCT2 is physically associated with EGFR in a molecular complex.
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Cetuximab downregulates ASCT2 via cetuximab-mediated EGFR endocytosis.
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Co-targeting ASCT2 by cetuximab sensitizes HNSCC cells to ROS-induced apoptosis.
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Cetuximab sensitizes ROS-induced apoptosis independent of EGFR kinase inhibition.