Cysteine is not a substrate but a specific modulator of human ASCT2 (SLC1A5) transporter
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- 作者：Mariafrancesca Scalisea ; Lorena Pochinia ; Piero Pingitorea ; Kristina Hedfalkb ; Cesare Indiveria ; cesare.indiveri@unical.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：C12E8 ; octaethylene glycol monododecyl ether ; MeAIB ; (α-methylamino)isobutyric acid ; BCH ; 2-aminobicyclo-(2 ; 2 ; 1)-heptane-2-carboxylic acid ; YPDS ; yeast extract peptone dextrose sorbitol ; BMGY ; buffered glycerol-complex medium ; DOC ; Na-deoxycholate ; NP-40 ; Nonidet ; NAC ; N-acetyl cysteine ; CMC ; carbossi methyl cysteine
- 刊名：FEBS Letters
- 出版年：2015
- 出版时间：30 November 2015
- 年：2015
- 卷：589
- 期：23
- 页码：3617-3623
- 全文大小：935 K
文摘
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The ASCT2 is involved in neutral amino acid transport by an antiport mechanism.
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The putative substrate Cys is not transported by the native or the recombinant hASCT2.
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By binding to a second site Cys triggers a protein-mediated unidirectional Gln efflux.