Carotid artery plaques and intima medial thickness in familial hypercholesteraemic patients on long-term statin therapy: A case control study

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• 作者：Sven Bos^a ; Martijne H.C. Duvekot^a ; Gert-Jan R. ten Kate^b ; Adrie J.M. Verhoeven^a ; Monique T. Mulder^a ; Arend F.L. Schinkel^b ; Koen Nieman^b ; ^c ; Gerald F. Watts^d ; Eric J.G. Sijbrands^a ; Jeanine E. Roeters van Lennep^a ; ¹ ; ^{j.roetersvanlennep@erasmusmc.nl}
• 关键词：Carotid plaque presence ; Carotid intima media thickness ; Familial hypercholesterolemia ; Residual risk
• 刊名：Atherosclerosis
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：256
• 期：Complete
• 页码：62-66
• 全文大小：225 K
• 卷排序：256

文摘

Carotid plaque and intima media thickness does not differ between statin-treated heterozygous FH patients and controls. This suggests a normalization of atherosclerotic cardiovascular disease (ASCVD) risk in statin-treated FH. Carotid IMT is not associated with coronary calcification in heterozygous FH patients. Carotid plaques are associated with coronary calcification in heterozygous FH patients. These findings suggest that sonography of carotid arteries during follow-up of statin-treated FH patients has limited value.