Emerging roles of PDGF-D signaling pathway in tumor development and progression

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• 作者：Zhiwei Wang ; Aamir Ahmad ; Yiwei Li ; Dejuan Kong ; Asfar S. Azmi ; Sanjeev Banerjee ; Fazlul H. Sarkar
• 关键词：PDGF-D ; Cancer ; Signaling ; Therapy ; Nutrition
• 刊名：Biochimica et Biophysica Acta (BBA)/Reviews on Cancer
• 出版年：2010
• 出版时间：August 2010
• 年：2010
• 卷：1806
• 期：1
• 页码：122-130
• 全文大小：781 K

文摘

Platelet-derived growth factor-D (PDGF-D) can regulate many cellular processes, including cell proliferation, apoptosis, transformation, migration, invasion, angiogenesis and metastasis. Therefore PDGF-D signaling has been considered to be important in human malignancies, and thus PDGF-D signaling may represent a novel therapeutic target, and as such suggests that the development of agents that will target PDGF-D signaling is likely to have a significant therapeutic impact on human cancers. This mini-review describes the mechanisms of signal transduction associated with PDGF-D signaling to support the role of PDGF-D in the carcinogenesis. Moreover, we summarize data on several PDGF-D inhibitors especially naturally occurring “chemopreventive agent” such an indole compound, which we believe could serve as a novel agent for the prevention of tumor progression and/or treatment of human malignancies by targeted inactivation of PDGF-D signaling.