Characteristic adaptations of the extracellular matrix in dilated cardiomyopathy
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- 作者：Laura Louzao-Martineza ; b ; Aryan Vinkc ; Magdalena Harakalovab ; c ; d ; Folkert W. Asselbergsb ; d ; e ; Marianne C. Verhaara ; Caroline Chenga ; f ; K.L.Cheng-2@umcutrecht.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Dilated cardiomyopathy (DCM) ; Extracellular matrix (ECM) ; Myocardial fibrosis ; Animal models ; Transcriptome ; Matrisome
- 刊名：International Journal of Cardiology
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：220
- 期：Complete
- 页码：634-646
- 全文大小：1280 K
文摘
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Dilated cardiomyopathy (DCM) involves extracellular matrix (ECM) adaptations.
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GEO datasets analysis reveals a novel transcriptome-based catalogue of ECM genes associated with dilated cardiomyopathy.
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ECM adaptations in DCM: 1) ECM synthesis and stabilization 2) fibroblast activity 3) collagens deposition 4) cell adhesion.