Conventional chemotherapy has limited efficacy to treat gastric cancer.
H. pylori CagA upregulated FUT4 with SP1 and HSF1 transcriptions.
Ginsenoside Rg3 (herbal medicine) induced cell apoptosis with FUT4 downregulation.
Rg3 induced apoptosis with FUT4 inhibition via SP1 and HSF1 transcription regulation.
Herbal therapy is a better strategy to treat gastric cancer with low toxicity.