Alteration of CD39 + Foxp3 + CD4 T cell and cytokine levels in EAE/MS following anti-CD52 treatment
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- 作者：Anudeep B. Pant ; Yan Wang ; Daniel W. Mielcarz ; Eli J. Kasper ; Kiel M. Telesford ; Megan Mishra ; Azizul Haque ; Azizul.Haque@Dartmouth.Edu ; Jacqueline Y. Channon ; Lloyd H. Kasper ; Sakhina Begum-Haque
- 关键词：MS ; multiple sclerosis ; RRMS ; relapsing remitting multiple sclerosis ; Treg ; T regulatory cell ; GALT ; gut associated lymphoid tissue ; EAE ; experimental autoimmune encephalomyelitis ; Anti-CD52 ; anti-CD52 antibody ; CLN ; cervical lymph node ; MLN ; mesenteric lymph node ; SPL ; spleen ; PP ; Peyer's patches ; CNS ; central nervous system ; PBMCs ; human peripheral blood mononuclear cells
- 刊名：Journal of Neuroimmunology
- 出版年：2017
- 出版时间：15 February 2017
- 年：2017
- 卷：303
- 期：Complete
- 页码：22-30
- 全文大小：1209 K
- 卷排序：303
文摘
Mice treated with murine anti-CD52 are protected against EAE disease progression. Synthesis of inflammatory cytokines is significantly suppressed following treatment. Enhanced IL-10 in plasma of EAE mice indicate treatment effect in periphery. Anti-CD52 treatment induces CD39 + regulatory T cells in EAE mice and MS patients.